Cancer Therapy: Preclinical Targeting Autophagy Augments In Vitro and In Vivo Antimyeloma Activity of DNA-Damaging Chemotherapy
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چکیده
Purpose: Although autophagy occurs in most tumor cells following DNA damage, it is still a mystery how this DNA-damaging event turns on the autophagy machinery in multiple myeloma (MM) and how the functional status of autophagy impacts on its susceptibility to death in response to DNA-damaging
منابع مشابه
Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy.
PURPOSE Although autophagy occurs in most tumor cells following DNA damage, it is still a mystery how this DNA-damaging event turns on the autophagy machinery in multiple myeloma (MM) and how the functional status of autophagy impacts on its susceptibility to death in response to DNA-damaging chemotherapy. EXPERIMENTAL DESIGN We investigate the effects of DNA damage on autophagy in MM cells a...
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تاریخ انتشار 2011